Stock fact sheet · data as of
Karyopharm Therapeutics Inc. (KPTI): fair value, margin of safety and Wheel Score
Healthcare · Biotechnology · United States · Speculative / Distressed
Is KPTI undervalued?
Karyopharm Therapeutics Inc. (KPTI) closed at 0.3508 on 16 Oct 2026. None of the nine GLS valuation models produced a positive value for the stock - the company lost money over the last twelve months, EPS -7.77, it pays no dividend and its debts exceed what its assets would fetch - so there is no GLS average fair value and no margin of safety to report. The quality, option and event numbers below still apply; the Quote page's Wall Street View shows what analysts expect instead.
The nightly engine files KPTI under Speculative / Distressed - negative earnings or a Piotroski score of 3 or less - which caps its Wheel Score at 45 and keeps it out of the Sunday Scan.
Nine valuation models for KPTI
Each model turns the latest filed numbers into a value per share; the GLS fair value is the simple average of the ones that produce a positive number. The last two rows are shown for reference and never enter the average. The Quote page lets you switch any model off and add your own margin of safety.
| Model | Value | vs price | What it measures |
|---|---|---|---|
| DCF | - | - | Present value of the projected free cash flows, discounted at the cost of capital; no value tonight |
| Graham Number | - | - | The most a defensive investor pays for the earnings and book value per share; no value tonight |
| Graham Growth | - | - | Graham's growth formula: EPS × (8.5 + 2 × growth), adjusted for bond yields; no value tonight |
| Lynch | - | - | EPS × the earnings growth rate (PEG of 1), growth capped at 25%; no value tonight |
| GLS Growth | - | - | EPS compounded ten years at the blended growth rate, discounted back at 15% a year; no value tonight |
| 10 Cap | - | - | Owner's earnings (operating cash flow less maintenance capex) capitalised at 10%; no value tonight |
| Payback Time | - | - | Eight years of compounded free cash flow: the price at which the business pays for itself; no value tonight |
| DDM | - | - | Dividend discount model: next year's dividend ÷ (10% − 3% growth); needs a dividend; no value tonight |
| EPV | - | - | Earnings power value: current EPS capitalised at 9% with no growth; no value tonight |
| Zombie (liquidation) | -13.15 | -3848% | Current assets less all liabilities, per share: the balance-sheet floor. Not in the average |
| Wall St target | 9.50 | +2608% | Analysts' average 12-month price target. Not in the average |
Quality and financial health
Financial health is weak: KPTI passes 2 of the nine Piotroski tests. Our screens drop the stock at the health rule; a low score is often the reason a stock looks cheap on the valuation models. The GLS Moat score is low at 1.5 out of 10, which says the ten-year record of revenue, earnings, margins and returns on capital has been inconsistent - growth and shocks rather than steady compounding.
Returns on capital are high - ROIC 330.5%, ROE 66.9%, ROA -180.8% - with debt at -0.80 times equity and negative free cash flow.
Karyopharm Therapeutics Inc. pays no dividend, so the DDM model does not apply and a covered-call holder earns only the premium and any price gain. Revenue comes mainly from License and Service 96%, Health Care, Other 4% (quarter Q2 FY2026).
Institutional ownership scores 10/10, insider activity 1/10 and Congressional trading 5/10 on the GLS smart-money scales.
| Piotroski F-score | 2 / 9 | ROIC | 330.5% |
|---|---|---|---|
| GLS Moat | 1.5 / 10 | ROE | 66.9% |
| Debt / equity | -0.80 | ROA | -180.8% |
| Free-cash-flow yield | -821.3% | Payout ratio | 0% |
| Institutions | 10 / 10 | Insiders · Congress | 1 · 5 / 10 |
Wheel Score 37: Weak
KPTI scores 37 out of 100 on the Wheel Score, in the Weak band (under 50). Value 13/25, Health 4/20, Moat 2/15, Premium 5/20, Stability 13/20. The score is not a judgement on the company; it says the price, quality and premium do not line up for selling puts on it today.
Implied volatility is 285%, far above the range the wheel strategy is built for. The premium looks generous; the Wheel Score gives it only 5 of 20 Premium points because moves of that size can blow through any strike. The option chain is deep: 65,444 contracts of open interest across all expiries, which means tight fills at most strikes.
Volume runs at 1.3M shares a day on a market cap of $8M, with a beta of 1.04; the Stability part of the Wheel Score gives that 13 of 20.
| Part | Points | From | |
|---|---|---|---|
| Value | 13 / 25 | 0% margin of safety | |
| Health | 4 / 20 | Piotroski 2/9 | |
| Moat | 2 / 15 | moat 1.5/10 | |
| Premium | 5 / 20 | implied volatility 285% | |
| Stability | 13 / 20 | 1.3M shares/day, $8M cap, beta 1.04 |
The Wheel Score ranks ~7,400 US stocks for selling cash-secured puts and covered calls; it is updated nightly and is not a recommendation. The walkthrough lesson shows how the score fits into a trade, start to finish.
Upcoming events
The next earnings report is due on 2 Nov 2026 (before the open), 17 days away; a 30-45-day put sold today would expire after it, which is worth weighing against the premium.
Earnings, dividend, IPO, split and economic calendars for the whole market, filterable to your watchlists.
Similar stocks in Biotechnology
The 12 companies below are the closest to Karyopharm Therapeutics Inc. by market cap within the Biotechnology industry, each with its own fact sheet; the Compare page puts up to eight of them side by side.
| Stock | Close | Fair value | MoS | Wheel | Mkt cap |
|---|---|---|---|---|---|
| CMMB Chemomab Therapeutics Ltd. | 1.29 | 1.56 | +17% | 28No options | $8M |
| APRE Aprea Therapeutics, Inc. | 0.6176 | 2.14 | +71% | 38No options | $8M |
| BOLT Bolt Biotherapeutics, Inc. | 4.24 | - | - | 27No options | $8M |
| XCUR Exicure, Inc. | 1.21 | 0.3541 | -242% | 4No options | $8M |
| QNRX Quoin Pharmaceuticals, Ltd. | 4.10 | 2,547.50 | +100% | 35No options | $8M |
| ADIL Adial Pharmaceuticals, Inc. | 3.14 | 7.98 | +61% | 37No options | $8M |
| CURX Curanex Pharmaceuticals Inc Common Stock | 4.83 | 3.26 | -48% | 13No options | $8M |
| CNSP CNS Pharmaceuticals, Inc. | 5.18 | 7.71 | +33% | 35No options | $8M |
| SNTI Senti Biosciences, Inc. | 0.2408 | - | - | 23No options | $7M |
| LTRN Lantern Pharma Inc. | 0.6668 | - | - | 27Weak | $9M |
| SNGX Soligenix, Inc. | 0.3407 | 1.27 | +73% | 35No options | $7M |
| ICU SeaStar Medical Holding Corporation | 3.06 | 3.09 | +1% | 29No options | $9M |
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Start free See the Sunday ScanQuestions about KPTI
Is KPTI undervalued right now?
The GLS models could not value KPTI (the company lost money over the last twelve months, EPS -7.77, it pays no dividend and its debts exceed what its assets would fetch), so there is no fair value or margin of safety to compare the price of 0.3508 against.
What is the Wheel Score of KPTI and what does it mean?
KPTI scores 37 out of 100 (Weak). The Wheel Score blends the margin of safety (25 points), Piotroski health (20), the GLS moat (15), the option premium on offer (20) and trading stability (20) into one number that ranks stocks for the wheel strategy - selling cash-secured puts, then covered calls if assigned. 80 and above is Prime, 65-79 Good, 50-64 Fair, under 50 Weak.
What is the GLS fair value for KPTI?
None of the nine GLS models produced a positive value for KPTI (the company lost money over the last twelve months, EPS -7.77, it pays no dividend and its debts exceed what its assets would fetch), so there is no GLS fair value tonight.
When does Karyopharm Therapeutics Inc. report earnings next?
The next earnings report is due on 2 Nov 2026 (before the open), 17 days from the data date of 16 Oct 2026. The Calendars page lists every upcoming report with its time of day.
Does KPTI have listed options, and how liquid are they?
Yes. The nightly snapshot found 152 listed contracts with 65,444 open interest across all expiries and implied volatility of 285% on the near-the-money contracts. The Options scanner lists the cash-secured put and covered call set-ups with premium and annualised yield worked out.