Stock fact sheet · data as of
Septerna Inc (SEPN): fair value, margin of safety and Wheel Score
Healthcare · Biotechnology · United States · Speculative / Distressed
Is SEPN undervalued?
SEPN closed at 36.32 on 16 Oct 2026, 22% below the GLS average fair value of 46.79 from 1 models (1 of them above the price). That is a moderate margin of safety: the stock passes the "below fair value" rule of the Sunday Scan, and the Wheel Score gives it 22 of the 25 Value points.
Only 1 of the nine models produced a value (10 Cap); the others need a dividend, positive free cash flow or positive book value the company does not have yet, so the average rests on a narrow base.
The nightly engine files SEPN under Speculative / Distressed - negative earnings or a Piotroski score of 3 or less - which caps its Wheel Score at 45 and keeps it out of the Sunday Scan.
Nine valuation models for SEPN
Each model turns the latest filed numbers into a value per share; the GLS fair value is the simple average of the ones that produce a positive number. The last two rows are shown for reference and never enter the average. The Quote page lets you switch any model off and add your own margin of safety.
| Model | Value | vs price | What it measures |
|---|---|---|---|
| DCF | - | - | Present value of the projected free cash flows, discounted at the cost of capital; no value tonight |
| Graham Number | - | - | The most a defensive investor pays for the earnings and book value per share; no value tonight |
| Graham Growth | - | - | Graham's growth formula: EPS × (8.5 + 2 × growth), adjusted for bond yields; no value tonight |
| Lynch | - | - | EPS × the earnings growth rate (PEG of 1), growth capped at 25%; no value tonight |
| GLS Growth | - | - | EPS compounded ten years at the blended growth rate, discounted back at 15% a year; no value tonight |
| 10 Cap | 46.79 | +29% | Owner's earnings (operating cash flow less maintenance capex) capitalised at 10% |
| Payback Time | - | - | Eight years of compounded free cash flow: the price at which the business pays for itself; no value tonight |
| DDM | - | - | Dividend discount model: next year's dividend ÷ (10% − 3% growth); needs a dividend; no value tonight |
| EPV | - | - | Earnings power value: current EPS capitalised at 9% with no growth; no value tonight |
| Zombie (liquidation) | 4.21 | -88% | Current assets less all liabilities, per share: the balance-sheet floor. Not in the average |
| Wall St target | 50.40 | +39% | Analysts' average 12-month price target. Not in the average |
Quality and financial health
Financial health is weak: SEPN passes 3 of the nine Piotroski tests. Our screens drop the stock at the health rule; a low score is often the reason a stock looks cheap on the valuation models. The GLS Moat score is low at 2.7 out of 10, which says the ten-year record of revenue, earnings, margins and returns on capital has been inconsistent - growth and shocks rather than steady compounding.
Returns on capital are thin or negative - ROIC -12.1%, ROE -12.8%, ROA -8.2% - with debt at 0.06 times equity and a free-cash-flow yield of 6.2%.
Septerna Inc pays no dividend, so the DDM model does not apply and a covered-call holder earns only the premium and any price gain.
Institutional ownership scores 10/10, insider activity 1/10 and Congressional trading 5/10 on the GLS smart-money scales.
| Piotroski F-score | 3 / 9 | ROIC | -12.1% |
|---|---|---|---|
| GLS Moat | 2.7 / 10 | ROE | -12.8% |
| Debt / equity | 0.06 | ROA | -8.2% |
| Free-cash-flow yield | 6.2% | Payout ratio | 0% |
| Institutions | 10 / 10 | Insiders · Congress | 1 · 5 / 10 |
Wheel Score 45: Weak
SEPN scores 45 out of 100 on the Wheel Score, in the Weak band (under 50), capped at 45 because the engine files it as Speculative / Distressed. Value 22/25, Health 7/20, Moat 4/15, Premium 15/20, Stability 9/20. The score is not a judgement on the company; it says the price, quality and premium do not line up for selling puts on it today.
Implied volatility is 80% on the near-the-money contracts 20-60 days out - above the 60% ceiling of the sweet spot. Premiums are large, but the Wheel Score tapers the Premium points (15 of 20) because volatility this high usually comes with a reason. Chain open interest is 2,489 contracts across all expiries - enough for the wheel at normal size.
Volume runs at 370k shares a day on a market cap of $1.7B, with a beta of 2.28 - a high beta, so the stock tends to move more than the market and a strike can be gapped through; the Stability part of the Wheel Score gives that 9 of 20.
| Part | Points | From | |
|---|---|---|---|
| Value | 22 / 25 | 22% margin of safety | |
| Health | 7 / 20 | Piotroski 3/9 | |
| Moat | 4 / 15 | moat 2.7/10 | |
| Premium | 15 / 20 | implied volatility 80% | |
| Stability | 9 / 20 | 370k shares/day, $1.7B cap, beta 2.28 |
The Wheel Score ranks ~7,400 US stocks for selling cash-secured puts and covered calls; it is updated nightly and is not a recommendation. The walkthrough lesson shows how the score fits into a trade, start to finish.
Upcoming events
The next earnings report is due on 9 Nov 2026, 24 days away; a 30-45-day put sold today would expire after it, which is worth weighing against the premium.
Earnings, dividend, IPO, split and economic calendars for the whole market, filterable to your watchlists.
Similar stocks in Biotechnology
The 12 companies below are the closest to Septerna Inc by market cap within the Biotechnology industry, each with its own fact sheet; the Compare page puts up to eight of them side by side.
| Stock | Close | Fair value | MoS | Wheel | Mkt cap |
|---|---|---|---|---|---|
| GENB Generate Biomedicines, Inc. | 13.06 | - | - | 45Weak | $1.7B |
| TRVI Trevi Therapeutics, Inc. | 12.06 | 0.1068 | -11195% | 39Weak | $1.7B |
| BHVN Biohaven Ltd. | 11.43 | - | - | 41Weak | $1.7B |
| NUVB Nuvation Bio Inc. | 4.75 | 3.07 | -55% | 38Weak | $1.7B |
| XNCR Xencor, Inc. | 23.39 | - | - | 39Weak | $1.7B |
| VIR Vir Biotechnology, Inc. | 10.41 | - | - | 45Weak | $1.8B |
| PVLA Palvella Therapeutics, Inc. | 122.58 | 4.71 | -2501% | 40Weak | $1.8B |
| OCUL Ocular Therapeutix, Inc. | 7.38 | - | - | 42Weak | $1.6B |
| ZBIO Zenas BioPharma, Inc. | 24.86 | - | - | 45Weak | $1.6B |
| ZYME Zymeworks Inc. | 24.77 | - | - | 45Weak | $1.8B |
| SRPT Sarepta Therapeutics, Inc. | 16.83 | - | - | 45Weak | $1.8B |
| XERS Xeris Biopharma Holdings, Inc. | 9.77 | 6.45 | -51% | 41Weak | $1.8B |
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Start free See the Sunday ScanQuestions about SEPN
Is SEPN undervalued right now?
By the GLS models, moderately: at 36.32 the stock trades 22% below the average fair value of 46.79 (data as of 16 Oct 2026).
What is the Wheel Score of SEPN and what does it mean?
SEPN scores 45 out of 100 (Weak). The Wheel Score blends the margin of safety (25 points), Piotroski health (20), the GLS moat (15), the option premium on offer (20) and trading stability (20) into one number that ranks stocks for the wheel strategy - selling cash-secured puts, then covered calls if assigned. 80 and above is Prime, 65-79 Good, 50-64 Fair, under 50 Weak.
What is the GLS fair value for SEPN?
46.79 per share as of 16 Oct 2026 - the simple average of the 1 valuation models (out of nine: DCF, Graham Number, Graham Growth, Lynch, GLS Growth, 10 Cap, Payback Time, DDM and EPV) that produced a positive value. The models run every night on the latest filings; the Quote page lets you switch any of them off and add a margin of safety of your own.
When does Septerna Inc report earnings next?
The next earnings report is due on 9 Nov 2026, 24 days from the data date of 16 Oct 2026. The Calendars page lists every upcoming report with its time of day.
Does SEPN have listed options, and how liquid are they?
Yes. The nightly snapshot found 284 listed contracts with 2,489 open interest across all expiries and implied volatility of 80% on the near-the-money contracts. The Options scanner lists the cash-secured put and covered call set-ups with premium and annualised yield worked out.