Stock fact sheet · data as of
Zymeworks Inc. (ZYME): fair value, margin of safety and Wheel Score
Healthcare · Biotechnology · United States · Speculative / Distressed
Is ZYME undervalued?
At 24.77 (close of 16 Oct 2026), ZYME has no GLS fair value: every one of the nine models needs a positive input (the company lost money over the last twelve months, EPS -2.05 and it pays no dividend), so the margin of safety is blank and the Wheel Score cannot be computed. Our screens leave the stock out at the first rule. What can be said from the nightly row is below.
The nightly engine files ZYME under Speculative / Distressed - negative earnings or a Piotroski score of 3 or less - which caps its Wheel Score at 45 and keeps it out of the Sunday Scan.
Nine valuation models for ZYME
Each model turns the latest filed numbers into a value per share; the GLS fair value is the simple average of the ones that produce a positive number. The last two rows are shown for reference and never enter the average. The Quote page lets you switch any model off and add your own margin of safety.
| Model | Value | vs price | What it measures |
|---|---|---|---|
| DCF | - | - | Present value of the projected free cash flows, discounted at the cost of capital; no value tonight |
| Graham Number | - | - | The most a defensive investor pays for the earnings and book value per share; no value tonight |
| Graham Growth | - | - | Graham's growth formula: EPS × (8.5 + 2 × growth), adjusted for bond yields; no value tonight |
| Lynch | - | - | EPS × the earnings growth rate (PEG of 1), growth capped at 25%; no value tonight |
| GLS Growth | - | - | EPS compounded ten years at the blended growth rate, discounted back at 15% a year; no value tonight |
| 10 Cap | - | - | Owner's earnings (operating cash flow less maintenance capex) capitalised at 10%; no value tonight |
| Payback Time | - | - | Eight years of compounded free cash flow: the price at which the business pays for itself; no value tonight |
| DDM | - | - | Dividend discount model: next year's dividend ÷ (10% − 3% growth); needs a dividend; no value tonight |
| EPV | - | - | Earnings power value: current EPS capitalised at 9% with no growth; no value tonight |
| Zombie (liquidation) | 2.17 | -91% | Current assets less all liabilities, per share: the balance-sheet floor. Not in the average |
| Wall St target | 41.40 | +67% | Analysts' average 12-month price target. Not in the average |
Quality and financial health
Zymeworks Inc. scores only 2 of 9 on the Piotroski F-score, which fails the Sunday Scan's "6 or more" rule. A reading this low means several of the basic tests - positive earnings, positive operating cash flow, falling debt, no new share issuance - are not met. A GLS Moat score of 1.8/10 is a weak reading: the ten-year history the score grades (revenue, EPS, book value, margins, cash flow, share count, ROIC) has not been steady, so the Moat part of the Wheel Score contributes little.
Returns on capital are thin or negative - ROIC -28.3%, ROE -30.2%, ROA -23.4% - with debt at 0.07 times equity and negative free cash flow.
Zymeworks Inc. pays no dividend, so the DDM model does not apply and a covered-call holder earns only the premium and any price gain. Revenue comes mainly from Royalty 85%, Research Support Payments And Other Ser… 16% (quarter Q2 FY2026).
Institutional ownership scores 10/10, insider activity 1/10 and Congressional trading 5/10 on the GLS smart-money scales.
| Piotroski F-score | 2 / 9 | ROIC | -28.3% |
|---|---|---|---|
| GLS Moat | 1.8 / 10 | ROE | -30.2% |
| Debt / equity | 0.07 | ROA | -23.4% |
| Free-cash-flow yield | -6.8% | Payout ratio | 0% |
| Institutions | 10 / 10 | Insiders · Congress | 1 · 5 / 10 |
Wheel Score 45: Weak
With a Wheel Score of 45 Zymeworks Inc. sits in the Weak band, capped at 45 because the engine files it as Speculative / Distressed. The parts - Value 13/25, Health 4/20, Moat 3/15, Premium 17/20, Stability 14/20 - show where: Health (4/20) scores lowest.
Implied volatility is 70% on the near-the-money contracts 20-60 days out - above the 60% ceiling of the sweet spot. Premiums are large, but the Wheel Score tapers the Premium points (17 of 20) because volatility this high usually comes with a reason. Chain open interest is 8,939 contracts across all expiries - enough for the wheel at normal size.
Volume runs at 559k shares a day on a market cap of $1.8B, with a beta of 1.17; the Stability part of the Wheel Score gives that 14 of 20.
| Part | Points | From | |
|---|---|---|---|
| Value | 13 / 25 | 0% margin of safety | |
| Health | 4 / 20 | Piotroski 2/9 | |
| Moat | 3 / 15 | moat 1.8/10 | |
| Premium | 17 / 20 | implied volatility 70% | |
| Stability | 14 / 20 | 559k shares/day, $1.8B cap, beta 1.17 |
The Wheel Score ranks ~7,400 US stocks for selling cash-secured puts and covered calls; it is updated nightly and is not a recommendation. The walkthrough lesson shows how the score fits into a trade, start to finish.
Upcoming events
The next earnings report is due on 5 Nov 2026 (after the close), 20 days away; a 30-45-day put sold today would expire after it, which is worth weighing against the premium.
Earnings, dividend, IPO, split and economic calendars for the whole market, filterable to your watchlists.
Similar stocks in Biotechnology
The 12 companies below are the closest to Zymeworks Inc. by market cap within the Biotechnology industry, each with its own fact sheet; the Compare page puts up to eight of them side by side.
| Stock | Close | Fair value | MoS | Wheel | Mkt cap |
|---|---|---|---|---|---|
| SRPT Sarepta Therapeutics, Inc. | 16.83 | - | - | 45Weak | $1.8B |
| XERS Xeris Biopharma Holdings, Inc. | 9.77 | 6.45 | -51% | 41Weak | $1.8B |
| URGN UroGen Pharma Ltd. | 36.58 | - | - | 45Weak | $1.8B |
| PVLA Palvella Therapeutics, Inc. | 122.58 | 4.71 | -2501% | 40Weak | $1.8B |
| VIR Vir Biotechnology, Inc. | 10.41 | - | - | 45Weak | $1.8B |
| MESO Mesoblast Limited | 13.95 | - | - | 45Weak | $1.8B |
| XNCR Xencor, Inc. | 23.39 | - | - | 39Weak | $1.7B |
| BHVN Biohaven Ltd. | 11.43 | - | - | 41Weak | $1.7B |
| TRVI Trevi Therapeutics, Inc. | 12.06 | 0.1068 | -11195% | 39Weak | $1.7B |
| SEPN Septerna Inc | 36.32 | 46.79 | +22% | 45Weak | $1.7B |
| GENB Generate Biomedicines, Inc. | 13.06 | - | - | 45Weak | $1.7B |
| NUVB Nuvation Bio Inc. | 4.75 | 3.07 | -55% | 38Weak | $1.7B |
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Start free See the Sunday ScanQuestions about ZYME
Is ZYME undervalued right now?
The GLS models could not value ZYME (the company lost money over the last twelve months, EPS -2.05 and it pays no dividend), so there is no fair value or margin of safety to compare the price of 24.77 against.
What is the Wheel Score of ZYME and what does it mean?
ZYME scores 45 out of 100 (Weak). The Wheel Score blends the margin of safety (25 points), Piotroski health (20), the GLS moat (15), the option premium on offer (20) and trading stability (20) into one number that ranks stocks for the wheel strategy - selling cash-secured puts, then covered calls if assigned. 80 and above is Prime, 65-79 Good, 50-64 Fair, under 50 Weak.
What is the GLS fair value for ZYME?
None of the nine GLS models produced a positive value for ZYME (the company lost money over the last twelve months, EPS -2.05 and it pays no dividend), so there is no GLS fair value tonight.
When does Zymeworks Inc. report earnings next?
The next earnings report is due on 5 Nov 2026 (after the close), 20 days from the data date of 16 Oct 2026. The Calendars page lists every upcoming report with its time of day.
Does ZYME have listed options, and how liquid are they?
Yes. The nightly snapshot found 102 listed contracts with 8,939 open interest across all expiries and implied volatility of 70% on the near-the-money contracts. The Options scanner lists the cash-secured put and covered call set-ups with premium and annualised yield worked out.